Coxibs

Coxibs block COX-2 (cyclooyygenase-2), an enzyme that promotes joint inflammation, while sparing another similar enzyme called COX-1, which helps protect the mucous lining in the stomach. A medication that blocks both COX-1 and COX-2 from doing their job (like ASA and traditional NSAID) will reduce joint inflammation, but will also put the stomach at risk for ulcers.

To get around this problem, scientists have developed drugs that block the effects of COX-2 while sparing COX-1 -- these are Coxibs. With these medications, we can get the beneficial effect of less joint inflammation and still keep the stomach lining in tact. The Coxib currently available in Canada is called celecoxib (Celebrex).

Side Effects

Although the Coxibs are much safer on the stomach than traditional NSAIDs, they still have potential side effects. Like other nonsterodial anti-inflammatory drugs, they may cause stomach upset, diarrhea, abdominal cramps and headaches. Some can contribute to high blood pressure, swelling of the feet ad ankles, as well as have effects on the function of the liver and kidneys.

Coxibs can sometimes interfere with other medications. It is important that you let your doctor  know all of the other drugs you are taking and any allergies to medications that you have. Celebrex belongs to a family of drugs called sulfonamides. If you have a known allergy to sulfa drugs, this drug should not be used. Celebrex should not be taken by patients who have aspirin-sensitive asthma or allergic reations to aspirin or other arthritis medications.

Your doctor will help select the Coxib that is right for you and monitor for side effects.

If you haven't already, make sure you visit NSAIDs: General Indications.

This page was last reviewed/updated on : 02/23/2008